Thalidomide reduces tumour necrosis factor-α production by human alveolar macrophages
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Tumour necrosis factor-alpha production in human alveolar macrophages: modulation by inhaled corticosteroid.
Using an ex vivo alveolar macrophage model, the hypothesis that inhaled preparations of corticosteroids might have important anti-inflammatory effects on cells of the peripheral airway was tested. The tumour necrosis factor (TNF)-alpha-inducing potential of three glycolipid preparations from nonpathogenic (arabinofuranasyl lipoarabinomannan (LAM (Ara-LAM)) and virulent (mannase LAM (ManLAM)) my...
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Recurrent infections of the lower respiratory tract are a frequent and serious side-effect of chronic corticosteroid treatment. Since alveolar macrophages (AM) are currently thought to play a central role in the protection of the lower respiratory tract against infectious agents, it is likely that a steroid-induced deficiency of AM is involved in this process. In this respect, when activated, A...
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Some biological effects of chronic cigarette smoking (two cigarettes for 2 h, daily for 4 months) in rats were evaluated. During the smoking period, body weight of smoker rats was always significantly lower than that of control rats. Immediately after the last smoking session the carboxyhaemoglobin concentration in the blood was about 8.5% and the polymorphonuclear cells in the bronchoalveolar ...
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1 OOS 36th Annual Aspen Lung Conference time I sc’mmc’e of a grouup 2 PLA,, no sPLA, mnRNA was dletec’tath)le by RT-PCR iui resting or primed PMN or imi FII,-6() cells (tumsciif’f’eremutiatecl and alt 3 amid 5 dlaivs d)f differeumtiattioum), sumggestimmg thmatt time PM N enzy’mne is distiumc’t l’roumi time kmiowmu group 2 sPLA, idlemmtifiedi imi other cells (platelets, liver celis, etc). To stu...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 1997
ISSN: 0954-6111
DOI: 10.1016/s0954-6111(97)90134-7